Publications

  1. R. Vanbever, N. Lecouturier and V. Préat, Transdermal delivery of metoprolol by electroporation, Pharm. Res. 11 : 1657-1662, 1994.
  2. R. Vanbever and V. Préat, Factors affecting transdermal delivery of metoprolol by electroporation, Bioelectrochem. Bioenerget. 38 : 223-228, 1995.
  3. R. Vanbever, E. Le Boulengé and V. Préat, Transdermal delivery of fentanyl by electroporation I. Influence of electrical factors, Pharm. Res. 13 : 559-565, 1996.
  4. R. Vanbever, N. De Morre and V. Préat, Transdermal delivery of fentanyl by electroporation II. Mechanisms involved in drug transport, Pharm. Res. 13 : 1360-66, 1996.
  5. J.C. Weaver, R. Vanbever, T.E. Vaughan, M.R. Prausnitz, Heparin alters transdermal transport associated with electroporation, Biochem. Biophys. Res. Com. 234 : 637-640, 1997.
  6. R. Vanbever, M.R. Prausnitz and V. Préat, Macromolecules as novel transdermal transport enhancers for skin electroporation, Pharm. Res. 14 : 638-644, 1997.
  7. R. Vanbever, G. Langers, S. Montmayeur and V. Préat, Transdermal delivery of fentanyl : rapid onset of analgesia using skin electroporation, J. Control. Release 50 : 225-235, 1998.
  8. R. Vanbever, D. Fouchard, A. Jadoul, N. De Morre, V. Préat and J.-P. Marty, In vivo non-invasive evaluation of hairless rat skin after high-voltage pulse exposure, Skin Pharmacol Appl. Skin Physiol. 11 : 23-34, 1998.
  9. R. Vanbever, M.-A. Leroy and V. Préat, Transdermal permeation of neutral molecules by electroporation, J. Control. Release 54 : 243-250, 1998.
  10. U. Pliquett, R. Vanbever, V. Préat and J.C. Weaver, Local transport regions (LTRs) in human stratum corneum due to long and short 'high voltage' pulses. Bioelectrochem. Bioenerget. 47 : 151-161, 1998.
  11. R. Vanbever and V. Préat, In vivo efficacy and safety of skin electroporation (invited review). Adv. Drug Deliv. Rev. 35 : 77-88, 1999.
  12. A. Ben-Jebria, D. Chen, M.-L. Eskew, R. Vanbever, R. Langer and D.A. Edwards, Large porous particles for sustained protection from carbachol-induced bronchoconstriction in guinea pigs. Pharm. Res. 16 : 555-561, 1999.
  13. R. Vanbever, U. Pliquett, V. Préat and J.C. Weaver, Comparison of the effects of short, high-voltage and long, medium-voltage pulses on skin electrical and transport properties. J. Control. Release 60 : 35-47, 1999.
  14. R. Vanbever, J.D. Mintzes, J. Wang, J. Nice, D. Chen, R. Batycky, R. Langer and D.A. Edwards, Formulation and physical characterization of large porous particles for inhalation. Pharm. Res. 16 : 1735-1742, 1999.
  15. R. Vanbever, A. Ben-Jebria, J.D. Mintzes, R. Langer and D.A. Edwards, Sustained-release of insulin from insoluble inhaled particles, Drug Dev. Res. 48 : 178-185, 1999.
  16. R. Vanbever, Administration transdermique de médicaments par électroporation. Bulletin et Mémoires de l’Académie royale de Médecine de Belgique 154 (6bis) : 327-333, 1999 (invited review).
  17. T.E. Zewert, U.F. Pliquett, R. Vanbever, R. Langer and J.C. Weaver, Creation of transdermal pathways for macromolecule transport by skin electroporation and a low toxicity, pathway-enlarging molecule Bioelectrochem. Bioenerget 49 : 11-20, 1999.
  18. M.R. Prausnitz, U. Pliquett and R. Vanbever, Mechanistic studies of skin electroporation using biophysical methods (invited book chapter). In : M.J. Jaroszeski, R. Gilbert, and R. Heller (eds), Electrochemotherapy, Electrogenetherapy, and Transdermal Delivery by Electroporation - Electrically-Mediated Delivery of Molecules to Cells, Humana Press pp 213-245, 1999.
  19. R. Vanbever and V. Préat, Transdermal drug delivery by skin electroporation in the rat (invited book chapter). In : M.J. Jaroszeski, R. Gilbert, and R. Heller (eds), Electrochemotherapy, Electrogenetherapy, and Transdermal Delivery by Electroporation - Electrically-Mediated Delivery of Molecules to Cells, Humana Press pp 457-471, 1999.
  20. C. Bosquillon, C. Lombry, V. Préat and R. Vanbever, Influence of formulation excipients and physical characteristics of inhalation dry powders on their aerosolization performance, J. Control. Release 70 : 329-339, 2001.
  21. V. Préat and R. Vanbever, Topical delivery by iontophoresis (invited book chapter). In : A. Barel, A. Maibach and M. Paye (eds), Handbook of Cosmetic Science and Technology, Marcel Dekker, pp 211-219, 2001.
  22. C. Bosquillon, C. Lombry, V. Préat and R. Vanbever, Comparison of particle sizing techniques in the case of inhalation dry powders. J. Pharm. Sci. 90 (12) : 2032-2041, 2001.
  23. C. Lombry, C. Bosquillon, V. Préat and R. Vanbever, Confocal imaging of rat lungs following intratracheal delivery of dry powders or solutions of fluorescent probes. J. Control. Release 83 (3) : 331-341, 2002.
  24. V. Préat and R. Vanbever, Skin electroporation for transdermal and topical drug delivery (invited book chapter). In : J. Hadgraft and R.H. Guy (eds), Transdermal Drug Delivery – Developmental Issues and Research Initiatives, Marcel Dekker, pp 227-254, 2003.
  25. V. Codrons, F. Vanderbist, R.K. Verbeeck, M. Arras, D. Lison, V. Préat and R. Vanbever, Systemic delivery of parathyroid hormone (1-34) using inhalation dry powders in rats. J. Pharm. Sci. 92 (5) : 938-950, 2003.
  26. R. Vanbever, Optimization of dry powder aerosols for systemic drug delivery (invited book chapter). In : J. Marijnissen and L. Gradon (eds), Optimization of Aerosol Drug Delivery, Kluwer, pp 91-103, 2003.
  27. C. Lombry, A. Marteleur, M. Arras, D. Lison, J. Louahed, J.-C. Renauld, V. Préat and R. Vanbever, Local and systemic immune responses to intratracheal instillation of antigen and DNA vaccines in mice. Pharm. Res. 21 (1) : 127-135, 2004.
  28. V. Codrons, F. Vanderbist, B. Ucakar, V. Préat and R. Vanbever, Impact of formulation and methods of pulmonary delivery on absorption of parathyroid hormone (1-34) from rat lungs. J. Pharm. Sci. 93 (5) : 1241-1252, 2004.
  29. C. Lombry, D.A. Edwards, V. Préat and R. Vanbever, Alveolar macrophages are a primary barrier to pulmonary absorption of macromolecules. Am. J. Physiol. Lung Cell Mol. Physiol. 286 : L1002-L1008, 2004.
  30. A.-R. Denet, R. Vanbever and V. Préat, Skin electroporation for transdermal and topical delivery (invited review). Adv. Drug Deliv. Rev. 56 : 659-674, 2004.
  31. C. Bosquillon, V. Préat and R. Vanbever, Pulmonary delivery of growth hormone using dry powders and visualization of its local fate in rats. J. Control. Release 96 : 233-244, 2004.
  32. C. Bosquillon, P. Rouxhet, F. Ahimou, D. Simon, Ch. Culot, V. Préat and R. Vanbever, Aerosolization properties, surface composition and physical state of spray-dried protein powders. J. Control. Release 99 : 357-367, 2004.
  33. R. Vanbever, Performance-driven, pulmonary delivery of systemically-acting drugs (invited review). Drug Discov. Today : Technologies 2 (1) : 39-46, 2005.
  34. J.Ducreux , R.Vanbever
    Crucial biopharmaceutical issues facing macromolecular candidates for inhalation : the role of macrophages in pulmonary protein clearance, Respiratory Drug Delivery Europe, 31-41
  35. A.Minne, J.Louahed, S.Mehauden, B.Baras, J.C.Renauld, R. Vanbever
    The delivery site of a monovalent influenza vaccine within the respiratory tract impacts on the immune response, Immunology, 122: 316-325
  36. A. Minne , J. Jaworska,K Gerhold,B. Ahrens, A. Avagyan,R. Vanbever, P.M. Matricardi, A.C. Schmidt, E. Hamelmann
    Intranasal delivery of whole influenza vaccine prevents subsequent allergen-induced sensitization and airway hyper-reactivity in mice, Clin.Exp.Allergy, 37:1250-1258
  37. A. Minne, F. Huaux, J. Jaworska, R.-D. Rha, E. Hamelmann, and R. Vanbever, Safety evaluation of pulmonary influenza vaccination in healthy and “asthmatic” mice (in preparation).
  38. A. Minne, H. Boireau, M. Joao-Horta and R. Vanbever, Development of an inhalation dry powder and assessment of its pulmonary distribution in mice (in preparation)
  39. J. Ducreux, P. Crocker and R. Vanbever, Pegylation of antibodies to sialoadhesin for increased binding inhibition to its ligand (in preparation).

Brevets
  1. J.C. Weaver, T. Chen, C. Cullander, R. Guy, R.S. Langer, T.E. Zewert, U.F. Pliquett, R. Vanbever, M.R. Prausnitz, Introduction of modifying agents into skin by electroporation. US 5,911,223; filed 8/9/96.
  2. D.A. Edwards, R.S. Langer, R. Vanbever, J. Mintzes, J. Wang, D. Chen, Preparation of particles for inhalation. US 5,985,309; filed 11/17/97.
  3. D.A. Edwards, J. Hanes, C. Evora, R.S. Langer, R. Vanbever, J. Mintzes, J. Wang, D. Chen, Preparation of particles for inhalation. WO 98/31346 and EP 0954282; filed 11/17/97.
  4. J.C. Weaver, U. Pliquett, R. Vanbever, T. Gowrishankar and T.E. Zewert, Biopotential measurements including electroporation of tissue surface. US 6,085,115; filed 5/22/98.
  5. D.A. Edwards, R.S. Langer, R. Vanbever, J. Mintzes, J. Wang, D. Chen, Preparation of novel particles for inhalation. US 6,652,837 B1; filed 9/13/99.
  6. D.A. Edwards, R.S. Langer, R. Vanbever, J. Mintzes, J. Wang, D. Chen, Particles for inhalation having sustained release properties. US 2002/0052310 A1; filed 12/29/00.
  7. R. Vanbever, R.S. Langer, D.A. Edwards, J. Mintzes, J. Wang, D. Chen, Particles for inhalation having sustained release properties. US 2003/0068277 A1; filed 3/07/02.
  8. R. Vanbever and D.A. Edwards, Chemical and physical modulators of bioavailability of inhaled compositions. US 10/843,693; filed 05/11/04.